AlphaSim necessary when using Z-maps in SPSS?

Submitted by evast001 on

Hi everyone

I'm using DPARSF to extract Z-maps between 8 seed regions which I then correlate in SPSS. The aim of my study is to relate resting state activity to a couple of behavioral measures. I realise that I need to conduct some form of multiple comparison correction on my correlations, but is it necessary for me to perform AlphaSim on my resting state data in DPARSF/REST before even taking it to SPSS? And if so, can someone please give me some insight on how to do this?

Thank you in advance.

/Eva

 

YAN Chao-Gan

Mon, 09/08/2014 - 20:00

Hi Eva,

In such a case (correlations between 8 seed regions), people don't do AlphaSim or GRF correction, as those took spatial extent into account -- which you don't have.

FDR correction is more appropriate in such a case. You will need to do FDR correction among the (8*7)/2 edges.

Best,

Chao-Gan

evast001

Thu, 09/11/2014 - 07:47

In reply to by YAN Chao-Gan

Hi, Chao-Gan

Thank you for your quick reply. I must admit I'm not sure how to conduct such a correction (FDR correction among the (8*7)/2 edges). It's the edges part that I can't really wrap my head around.

/Eva

:-)  Sadly, I don't have any facebook friends remotely interested in MRI research... I think I will work something out.

On a completely different note, I just started looking at DPABI and it's looking really good. I'm wondering how similar it is to DPARSF? Is it possible to take files generated from DPARSF (from pre-processing for example) and put them into DPABI for various statistical analysis, or is it necessary to do everything over again using DPABI?

Thank you!

/Eva