using REST-GCA for fMRI, especially apply the signed-path coefficients

Submitted by forestfan on

Normally, the HRF is non-stationay and differs across regions. How to do the GCA using REST-GCA, especially the signed-path coefficients. Do I have to extract the fMRI time-series before spatial smoothingfrom ROIs and remove the global signal for making the BOLD time series more stationary for GCA??