Functional connectivity between ROI and itself

Submitted by chiang on Tue, 09/02/2014 - 09:43

Dear everyone,

--I did a paired T-test analysis on ALFF data that from before (PreTest) and after (PostTest) an intervention. Let's supposed that one regions (A) survived after correction of multiple comparison.

--Then, we did voxel-based fucntional connectivity between A and all other voxels in the whole brain. Then, paired T-test was used again and found a significantly different region (B). However, region B almost the same as region A (most voxels overlep).

Now, i want to know whether the result (region B) is reasonable? How to interpret this kind of result?

Thanks a lot!

Hi Haijiang,

In considering R-fMRI theoretic wise, this is reasonable. According to MoLFF which I am working on currently, functional connectivity should have two components: modulation strength (phase amplitude coupling strength) and phase difference, please see http://rfmri.org/MoLFF, especially 27:30.

But I will still encourage you to double check all your analyses are correct!

Best,

Chao-Gan

Hi, Dr. Yan

Thank you for your kindly reply. I will check the data and analyses as you suggested.

I have another question, Do you think Independent component analysis (ICA) can make the result more solid? I mean if conducted a group ICA and find the component that mostly correlate with the seed-based functional connectivity map, then compare the difference between pre and post compnent. If i found the difference just at the same region as abovementioned. Then, i can trust the results?

Thanks,