[PRN_151206001]DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging

DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging

Chao-Gan Yan1,2, Xin-Di Wang3, Xi-Nian Zuo1, Yu-Feng Zang4,5

1Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; 2Department of Child and Adolescent Psychiatry, NYU Langone Medical Center School of Medicine, New York, NY, USA; 3State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; 4Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China; 5Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, China

Corresponding author:

Chao-Gan Yan, Ph.D.

Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China

16 Lincui Road, Chaoyang District, Beijing 100101, China

Tel: +86-10-64101582

Fax: +86-10-64101582

E-mail: ycg.yan@gmail.com

ABSTRACT

Brain imaging efforts are being increasingly devoted to decode the functioning of the human brain. Among neuroimaging techniques, resting-state fMRI (R-fMRI) is currently expanding exponentially. Beyond the general neuroimaging analysis packages (e.g., SPM, AFNI and FSL), REST and DPARSF were developed to meet the increasing need of user-friendly toolboxes for R-fMRI data processing. To address recently identified methodological challenges of R-fMRI, we introduce the newly developed toolbox, DPABI, which was evolved from REST and DPARSF. DPABI incorporates recent research advances on head motion control and measurement standardization, thus allowing users to evaluate results using stringent control strategies. DPABI also emphasizes test-retest reliability and quality control of data processing. Furthermore, DPABI provides a user-friendly pipeline analysis toolkit for rat/monkey R-fMRI data analysis to reflect the rapid advances in animal imaging. In addition, DPABI includes preprocessing modules for task-based fMRI, voxel-based morphometry analysis, statistical analysis and results viewing. DPABI is designed to make data analysis require fewer manual operations, be less time-consuming, have a lower skill requirement, a smaller risk of inadvertent mistakes, and be more comparable across studies. We anticipate this open-source toolbox will assist novices and expert users alike and continue to support advancing R-fMRI methodology and its application to clinical translational studies.

Keywords: data processing; quality control; resting-state fMRI; standardization; statistical analysis

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