Dear Dr. YAN Chao-Gan and experts,
I kindly ask you if you know studies that investigated the sensitivity of the rs-fMRI technique in the clinical setting, such as AD.
In particular I have been looking for studies with a large number of patients which possibly used the Receiver operator characteristic (ROC) analysis to assess the diagnostic power of the rs-fMRI technique.
Thank you for your help,
Cristina Rosazza
Hi Cristina,
Hi Cristina,
Depends on the clinical settings, R-fMRI technique has relatively good sensitivity.
Take AD as an example, we do have a classification analysis achiving a classification accuracy of 89.47%: Dai, Z., Yan, C., Wang, Z., Wang, J., Xia, M., Li, K., He, Y., 2012. Discriminative analysis of early Alzheimer's disease using multi-modal imaging and multi-level characterization with multi-classifier (M3). Neuroimage 59, 2187-2195.
In another study, we did use PCC ALFF do an ROC analysis: Wang, Z., Yan, C., Zhao, C., Qi, Z., Zhou, W., Lu, J., He, Y., Li, K., 2011. Spatial patterns of intrinsic brain activity in mild cognitive impairment and alzheimer's disease: A resting-state functional MRI study. Hum Brain Mapp 32, 1720-1740.
Best,
Chao-Gan