Questions about the lateralization analysis

谢谢回复，进一步还有一些问题： 1. 利用以下代码，对对称的mask“'35 subjects GM_Sym mask”制作其单侧为mask，输出为“Sym”，但生成的图像包含了全脑约2/3，而非一半，望分析下原因。 [Data Vox Head]=rest_readfile('35 subjects GM_Sym mask.nii'); Data(1:31,:,:)=0; rest_WriteNiftiImage(Data,Head,'Sym.nii'); 2. 我事实上是想在VMHC分析中，把VMHM作为covariate，每个subject制作一个VMHM map，这里不明白您说的所有被试整理成一个样子是什么意思？可否在DPARSFA中，直接输入mwco*的GM map，利用VMHC模块得出VMHM？ 3. 对左西年老师的一篇文章有不解之处： Title： Decreased interhemispheric coordination in schizophrenia: A resting state fMRI study In order to determine whether deficits in VMHC could be attributed to abnormalities in RSFC in one hemisphere or the other, we performed separate GLMs on the residualized time series data in nonsymmetric MNI space, with global VMHC and FD as covariates. Seeds (spheres with 4 mm radius) for these analyses were generated based on each local maximum and its homotopic homolog. These were thresholded at p=.05 (corrected for Gaussian Random Fields). To visualize these results, for each seed pair, we computed the right–left asymmetry in positive FC in the group difference region (see Fig. 2). These analyses showed that both hemispheres were involved in the observed effects. 根据这一步的结果图，我猜测可能是以VMHC异常区域为种子点，分别计算左右侧种子点与全脑其他区域的FC，然后对左右侧做一个paired t-test，观察是否有侧化效应，但感觉这样做意义很模糊，或者是否我理解错了，想看看您的看法。