修稿,答复审稿人的问题,求教

Submitted by yubing on

各位老师,大家好,我的一篇文章大修,是研究基因型与疾病关系的。

我首先用VBM,做了基因型与组间(正常/患病)的方差分析,得到有两个cluster存在交互作用,然后用这两个cluster做全脑的FC,再做FC的方差分析

审稿人除了指出样本和效应量的问题以外,还提出“Is there a bias for picking up ROI seeds correlated with GENE and then evaluating the relationship between GENE with the FC connected to these seed ROIs?'

不知道审稿人的这个问题怎么回答合适?多谢指教!

YAN Chao-Gan

Mon, 10/24/2016 - 22:48

There is no circulation as the first step only identifies the cluster with gray matter differences. There is no functional information (especially connectivity with other brain regions) was used.