老师您好!
在臧老师07年发表的论文中(Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI.Brain Development, 2007),统计部分two-sample t test采用了uncorrected的校正方式(A two-sample t-test was performed to see the ALFF difference between the two groups. Voxels with a P value <0.01 (uncorrected) and cluster size >270 mm3 (10 voxels) were considered to show significant difference between the two groups.)查阅其它ALFF相关文章后,发现关于ALFF的two-sample t test多采用此种分析方式,e.g:For ALFF comparison, a combined threshold of p < 0.005 and a minimum cluster size of 486 mm3 was used, which resulted into a corrected threshold of p < 0.05 determined by AlphaSim program in AFNI.(Abnormal spontaneous brain activity in medication-naïve ADHD children: A resting state fMRI study.Neuroscience Letters,2011).
我的问题是:1.采用此种校正方式,而不是FWE或FDR,是不是因为ALFF双样本T检验得到的结果通常在[-5,5]之间,无法进行FWE或FDR
2.这种校正方法和FWE/FDR有什么区别
3.虽然您07年的文献没有注明,文中采用的P value <0.01 (uncorrected) and cluster size >270 mm3 (10 voxels) 校正方式,是不是也对应着一个
corrected p value?
4.这种对p值uncorrected,又对体素个数进行限定的校正方式,是否和corrected p value有一一对应的关系?如果有,有公式可循吗?
不知道我是否描述清楚了问题,谢谢老师的耐心解答。
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