Statistics with GCA result

Submitted by WHJUNG on
Dear REST-GCA experts, I really appreciated your work about REST toolkit. I have been performing granger causality analysis with resting-state fMRI data in healthy controls and patients using REST-GCA toolkit. I performed both voxel-GCA and ROI-wise GCA. I am wondering how to conduct statistical analyses, e.g. within-group analysis and between-group comparison with the results acquired using REST-GCA toolkit? I think that we can not use one-sample t-test or two-sample t-test with the results. Do you have any description like ppt file to do statistics? I saw your files, Usage_of_REST-GCA_0.ppt and GCA_readme_New_Version_0.doc, but it didn't describe how to do statistical analysis. Your reply would be greatly appreciated. Thank you very much in advance for your help.

YAN Chao-Gan

Mon, 02/21/2011 - 14:37

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Hi! For the coefficient-based GCA, you may perform tests on the coefficients directly. See: Hamilton, J.P., Chen, G., Thomason, M.E., Schwartz, M.E., Gotlib, I.H., in press. Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data. Mol Psychiatry. For the residual-based GCA, ZANG Zhen-Xiang has a work to convert this value into normal distributed. You can see it from the next release of REST. Best wishes!

WHJUNG

Tue, 02/22/2011 - 00:47

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Thank you for your kind comment. It were a big help. I would use REST-GCA toolkit with our data. It is cited this software in my manuscript.
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