Is it possible to do the Functional connectivity analysis with not normalized data?


I would like to apply the functional connectivity analysis to patients who suffered lesions. Is it possible to use not normalized images? It seems that the 'DPARSF' does not allow this customization. Therefore, I am going to try to use SPM to pre-process the data then run the functional connectivity in REST2007. Would it be any problems in this way? Thank you very much in advance!

Happy Spring Festival!

Yong Li, PhD


Sure you can do FC without spatial normalization. The question is that it is difficult to compare the result with normal pattern.

You may encounter some problems when performing FC in individual space.
Please see some information from:
Best wishes!