Dear Experts,

In the resting state data information, the following is reported:

C - Covariates Removed (without global signal regression)

globalC - Covariates Removed (with global signal regression)

I was wondering exactly which covariates have been removed. Is this just motion parameters or also phisiological noise?

Thank you,

Leonardo Tozzi

Forums

## FunImgARCovs

Hi Leonardo:

You may check the .mat files in {working directory}/FunImgARCovs.

## For some reason, I cannot

For some reason, I cannot find this file, where is it relation to the folder containing the data (ROISignals_FunImgARCWF)?

Thank you,

Leonardo Tozzi

## You may run DPARSFA on the

You may run DPARSFA on the demo data to have a full comprehension on the covariates.

## Thank you very much!

Thank you very much!

Then is it correct to assume that the removed covariates are the default as in your Frontiers 2010 paper: https://www.frontiersin.org/articles/10.3389/fnsys.2010.00013/full

There you say:

"six motion parameters, the cerebrospinal fluid (CSF), and the white matter signals would also be removed as nuisance variables to reduce the effects of head motion and non-neuronal BOLD fluctuations"

## No. Now is Firston 24 head

No. Now is Firston 24 head motion parameter model. You can see Yan, C.G., Chen, X., Li, L., Castellanos, F.X., Bai, T.J., Bo, Q.J., Cao, J., Chen, G.M., Chen, N.X., Chen, W., Cheng, C., Cheng, Y.Q., Cui, X.L., Duan, J., Fang, Y.R., Gong, Q.Y., Guo, W.B., Hou, Z.H., Hu, L., Kuang, L., Li, F., Li, K.M., Li, T., Liu, Y.S., Liu, Z.N., Long, Y.C., Luo, Q.H., Meng, H.Q., Peng, D.H., Qiu, H.T., Qiu, J., Shen, Y.D., Shi, Y.S., Wang, C.Y., Wang, F., Wang, K., Wang, L., Wang, X., Wang, Y., Wu, X.P., Wu, X.R., Xie, C.M., Xie, G.R., Xie, H.Y., Xie, P., Xu, X.F., Yang, H., Yang, J., Yao, J.S., Yao, S.Q., Yin, Y.Y., Yuan, Y.G., Zhang, A.X., Zhang, H., Zhang, K.R., Zhang, L., Zhang, Z.J., Zhou, R.B., Zhou, Y.T., Zhu, J.J., Zou, C.J., Si, T.M., Zuo, X.N., Zhao, J.P., Zang, Y.F. (2019). Reduced default mode network functional connectivity in patients with recurrent major depressive disorder. Proc Natl Acad Sci U S A, 116(18), 9078-9083, doi:10.1073/pnas.1900390116.